It could be wrong or defective registry entry. The hardware malfunction could be a different important reason as the program is loaded on the hard drive. MFC100 Dll File is Missing Error in QuickBooks for Windows system folder (\\System32\\ / \\SysWOW64\\), but can also be found in the install directory of a program using the file. The program can't start because MSVCR100.dll is missing from your computer. Try reinstalling the program to fix this problem.