Hebei Shanghai Trading Co., Ltd CAS number 55981-09-4



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Good quality and low price [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate , Nitazoxanide 99.9% white powder MF Hebei Shanghai Trading Co., Ltd CAS number 55981-09-4


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<ol> <li>&nbsp;</li> </ol> <p>Nitazoxanide</p> <p>Common NameNitazoxanideCAS Number<a href=\"https://www.chemsrc.com/en/baike/831507.html\" target=\"_blank\">55981-09-4</a>Molecular Weight307.282Density1.5&plusmn;0.1 g/cm3Boiling PointN/AMolecular FormulaC12H9N3O5SMelting Point202&ordm;CMSDS<a href=\"javascript:void(0);\">USA</a>Flash PointN/ASymbol<br /> <a href=\"https://www.chemsrc.com/GHS.jsp#_pict\" target=\"_blank\">GHS07</a>Signal WordWarning</p> <p><em>&nbsp;</em>Use of Nitazoxanide</p> <p><br /> Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 &mu;M).Target: OthersNitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. In vitro studies demonstrated much broader activity. Dr. Rossignol co-founded Romark Laboratories, with the goal of bringing nitazoxanide to market as an anti-parasitic drug. Initial studies in the USA were conducted in collaboration with Unimed Pharmaceuticals, Inc. (Marietta, GA) and focused on development of the drug for treatment of cryptosporidiosis in AIDS.The anti-protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. It has also been shown to have activity against influenza A virus in vitro. The mechanism appears to be by selectively blocking the maturation of the viral hemagglutinin at a stage preceding resistance to endoglycosidase H digestion. This impairs hemagglutinin intracellular trafficking and insertion of the protein into the host plasma membrane.</p> <p>Nitazoxanide Biological Activity</p> <p>DescriptionNitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 &mu;M).Target: OthersNitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. In vitro studies demonstrated much broader activity. Dr. Rossignol co-founded Romark Laboratories, with the goal of bringing nitazoxanide to market as an anti-parasitic drug. Initial studies in the USA were conducted in collaboration with Unimed Pharmaceuticals, Inc. (Marietta, GA) and focused on development of the drug for treatment of cryptosporidiosis in AIDS.The anti-protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. It has also been shown to have activity against influenza A virus in vitro. The mechanism appears to be by selectively blocking the maturation of the viral hemagglutinin at a stage preceding resistance to endoglycosidase H digestion. This impairs hemagglutinin intracellular trafficking and insertion of the protein into the host plasma membrane.Related Catalog</p> <p><a href=\"https://www.chemsrc.com/en/CatgBio/3519.html\">Signaling Pathways</a> &gt;&gt; <a href=\"https://www.chemsrc.com/en/CatgBio/3561.html\">Autophagy</a> &gt;&gt; <a href=\"https://www.chemsrc.com/en/CatgBio/3562.html\">Autophagy</a></p> <p><a href=\"https://www.chemsrc.com/en/CatgBio/3519.html\">Signaling Pathways</a> &gt;&gt; <a href=\"https://www.chemsrc.com/en/CatgBio/3526.html\">Anti-infection</a> &gt;&gt; <a href=\"https://www.chemsrc.com/en/CatgBio/3537.html\">Influenza Virus</a></p> <p><a href=\"https://www.chemsrc.com/en/CatgBio/3520.html\">Research Areas</a> &gt;&gt; <a href=\"https://www.chemsrc.com/en/CatgBio/3939.html\">Infection</a></p> <p>Solvent</p> <p>In Vitro:</p> <p>10 mM in DMSO</p> <p>Solubility1 mM3.2544 mL16.2718 mL32.5436 mL5 mM0.6509 mL3.2544 mL6.5087 mL10 mM0.3254 mL1.6272 mL3.2544 mLStoragePowder-20&deg;C3 years&nbsp;4&deg;C2 yearsIn solvent-80&deg;C6 months&nbsp;-20&deg;C1 monthShippingRoom temperature in continental US; may vary elsewhereSMILESO=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2OC(C)=OReferences</p> <p>[1]. <a href=\"http://www.ncbi.nlm.nih.gov/pubmed/19638339\" target=\"_blank\">Rossignol JF, et al. Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level. J Biol Chem. 2009 Oct 23;284(43):29798-808.</a></p> <p>[2]. <a href=\"http://www.ncbi.nlm.nih.gov/pubmed/24412397\" target=\"_blank\">Somvanshi VS, et al. Nitazoxanide: Nematicidal mode of action and drug combination studies. Mol Biochem Parasitol. 2014 Jan 8;193(1):1-8.</a></p> <p>Related Molecules<a href=\"https://www.chemsrc.com/en/cas/1985605-59-1_1470253.html\" target=\"_blank\">Baloxavir</a> | <a href=\"https://www.chemsrc.com/en/cas/1629869-44-8_1466386.html\" target=\"_blank\">Pimodivir</a> | <a href=\"https://www.chemsrc.com/en/cas/1428729-56-9_1468632.html\" target=\"_blank\">KIN1148</a> | <a href=\"https://www.chemsrc.com/en/cas/139110-80-8_894690.html\" target=\"_blank\">Zanamivir</a> | <a href=\"https://www.chemsrc.com/en/cas/131707-23-8_324994.html\" target=\"_blank\">Arbidol HCl</a> | <a href=\"https://www.chemsrc.com/en/cas/341001-38-5_831376.html\" target=\"_blank\">Nucleozin</a> | <a href=\"https://www.chemsrc.com/en/cas/4670-05-7_1102772.html\" target=\"_blank\">Theaflavin</a> | <a href=\"https://www.chemsrc.com/en/cas/501-97-3_768185.html\" target=\"_blank\">Desaminotyrosine</a> | <a href=\"https://www.chemsrc.com/en/cas/1041434-82-5_268898.html\" target=\"_blank\">Peramivir Trihydrate</a> | <a href=\"https://www.chemsrc.com/en/cas/1428729-63-8_1471080.html\" target=\"_blank\">RIG-1 modulator 1</a> | <a href=\"https://www.chemsrc.com/en/cas/1501-84-4_838394.html\" target=\"_blank\">Rimantadine Hydrochloride</a> | <a href=\"https://www.chemsrc.com/en/cas/28302-36-5_1118242.html\" target=\"_blank\">Sodium copper chlorophyllin</a> | <a href=\"https://www.chemsrc.com/en/cas/615253-61-7_435078.html\" target=\"_blank\">SP187</a> | <a href=\"https://www.chemsrc.com/en/cas/134418-28-3_749638.html\" target=\"_blank\">Dehydroandrographolide</a> | <a href=\"https://www.chemsrc.com/en/cas/1190215-03-2_272158.html\" target=\"_blank\">M2 ion channel blocker</a></p> <p><em>&nbsp;</em>Chemical &amp; Physical Properties</p> <p>Density1.5&plusmn;0.1 g/cm3Melting Point202&ordm;CMolecular FormulaC12H9N3O5SMolecular Weight307.282Exact Mass307.026276PSA142.35000LogP1.79Index of Refraction1.673Storage condition-20&deg;C Freezer</p> <p><em>&nbsp;</em>MSDS</p> <hr /> <p><strong>SECTION 1: Identification of the substance/mixture and of the company/undertaking</strong><br /> <strong>Product identifiers</strong><br /> Product name: Nitazoxanide<br /> REACH No.: A registration number is not available for this substance as the substance<br /> or its uses are exempted from registration, the annual tonnage does not<br /> require a registration or the registration is envisaged for a later<br /> registration deadline.<br /> CAS-No.: 55981-09-4<br /> <strong>Relevant identified uses of the substance or mixture and uses advised against</strong><br /> Identified uses: Laboratory chemicals, Manufacture of substances<br /> <br /> &nbsp;</p> <hr /> <p><strong>SECTION 2: Hazards identification</strong><br /> <strong>Classification of the substance or mixture</strong><br /> <strong>Classification according to Regulation (EC) No 1272/2008</strong><br /> Acute toxicity, Oral (Category 4), H302<br /> Skin irritation (Category 2), H315<br /> Eye irritation (Category 2), H319<br /> Specific target organ toxicity - single exposure (Category 3), H335<br /> For the full text of the H-Statements mentioned in this Section, see Section 16.<br /> <strong>Classification according to EU Directives 67/548/EEC or 1999/45/EC</strong><br /> Xn HarmfulR22, R36/37/38<br /> For the full text of the R-phrases mentioned in this Section, see Section 16.<br /> <strong>Label elements</strong><br /> <strong>Labelling according Regulation (EC) No 1272/2008</strong><br /> Pictogram<br /> Signal wordWarning<br /> Hazard statement(s)<br /> H302Harmful if swallowed.<br /> H315Causes skin irritation.<br /> H319Causes serious eye irritation.<br /> H335May cause respiratory irritation.<br /> Precautionary statement(s)<br /> P261Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.<br /> P305 + P351 + P338IF IN EYES: Rinse cautiously with water for several minutes. Remove<br /> contact lenses, if present and easy to do. Continue rinsing.<br /> Supplemental Hazardnone<br /> Statements<br /> <strong>Other hazards - none</strong></p> <hr /> <p><strong>SECTION 3: Composition/information on ingredients</strong><br /> <strong>Substances</strong><br /> Formula: C12H9N3O5S<br /> Molecular Weight: 307,28 g/mol<br /> CAS-No.: 55981-09-4<br /> EC-No.: 259-931-8<br /> <strong>Hazardous ingredients according to Regulation (EC) No 1272/2008</strong><br /> ComponentClassificationConcentration<br /> <strong>Nitazoxanide</strong><br /> CAS-No.55981-09-4Acute Tox. 4; Skin Irrit. 2; Eye &lt;= 100 %<br /> EC-No.259-931-8Irrit. 2; STOT SE 3; H302,<br /> H315, H319, H335<br /> <strong>Hazardous ingredients according to Directive 1999/45/EC</strong><br /> ComponentClassificationConcentration<br /> <strong>Nitazoxanide</strong><br /> CAS-No.55981-09-4Xn, R22 - R36/37/38&lt;= 100 %<br /> EC-No.259-931-8<br /> For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16</p> <hr /> <p><strong>SECTION 4: First aid measures</strong><br /> <strong>Description of first aid measures</strong><br /> <strong>General advice</strong><br /> Consult a physician. Show this safety data sheet to the doctor in attendance.<br /> <strong>If inhaled</strong><br /> If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.<br /> <strong>In case of skin contact</strong><br /> Wash off with soap and plenty of water. Consult a physician.<br /> <strong>In case of eye


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