Nitazoxanide
Common NameNitazoxanideCAS Number55981-09-4Molecular Weight307.282Density1.5±0.1 g/cm3Boiling PointN/AMolecular FormulaC12H9N3O5SMelting Point202ºCMSDSUSAFlash PointN/ASymbol
GHS07Signal WordWarning
Use of Nitazoxanide
Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM).Target: OthersNitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. In vitro studies demonstrated much broader activity. Dr. Rossignol co-founded Romark Laboratories, with the goal of bringing nitazoxanide to market as an anti-parasitic drug. Initial studies in the USA were conducted in collaboration with Unimed Pharmaceuticals, Inc. (Marietta, GA) and focused on development of the drug for treatment of cryptosporidiosis in AIDS.The anti-protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. It has also been shown to have activity against influenza A virus in vitro. The mechanism appears to be by selectively blocking the maturation of the viral hemagglutinin at a stage preceding resistance to endoglycosidase H digestion. This impairs hemagglutinin intracellular trafficking and insertion of the protein into the host plasma membrane.
Nitazoxanide Biological Activity
DescriptionNitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM).Target: OthersNitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. In vitro studies demonstrated much broader activity. Dr. Rossignol co-founded Romark Laboratories, with the goal of bringing nitazoxanide to market as an anti-parasitic drug. Initial studies in the USA were conducted in collaboration with Unimed Pharmaceuticals, Inc. (Marietta, GA) and focused on development of the drug for treatment of cryptosporidiosis in AIDS.The anti-protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. It has also been shown to have activity against influenza A virus in vitro. The mechanism appears to be by selectively blocking the maturation of the viral hemagglutinin at a stage preceding resistance to endoglycosidase H digestion. This impairs hemagglutinin intracellular trafficking and insertion of the protein into the host plasma membrane.Related Catalog
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Signaling Pathways >> Anti-infection >> Influenza Virus
Solvent
In Vitro:
10 mM in DMSO
Solubility1 mM3.2544 mL16.2718 mL32.5436 mL5 mM0.6509 mL3.2544 mL6.5087 mL10 mM0.3254 mL1.6272 mL3.2544 mLStoragePowder-20°C3 years 4°C2 yearsIn solvent-80°C6 months -20°C1 monthShippingRoom temperature in continental US; may vary elsewhereSMILESO=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2OC(C)=OReferences
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Chemical & Physical Properties
Density1.5±0.1 g/cm3Melting Point202ºCMolecular FormulaC12H9N3O5SMolecular Weight307.282Exact Mass307.026276PSA142.35000LogP1.79Index of Refraction1.673Storage condition-20°C Freezer
MSDS
SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name: Nitazoxanide
REACH No.: A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No.: 55981-09-4
Relevant identified uses of the substance or mixture and uses advised against
Identified uses: Laboratory chemicals, Manufacture of substances
SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Acute toxicity, Oral (Category 4), H302
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Specific target organ toxicity - single exposure (Category 3), H335
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Xn HarmfulR22, R36/37/38
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal wordWarning
Hazard statement(s)
H302Harmful if swallowed.
H315Causes skin irritation.
H319Causes serious eye irritation.
H335May cause respiratory irritation.
Precautionary statement(s)
P261Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazardnone
Statements
Other hazards - none
SECTION 3: Composition/information on ingredients
Substances
Formula: C12H9N3O5S
Molecular Weight: 307,28 g/mol
CAS-No.: 55981-09-4
EC-No.: 259-931-8
Hazardous ingredients according to Regulation (EC) No 1272/2008
ComponentClassificationConcentration
Nitazoxanide
CAS-No.55981-09-4Acute Tox. 4; Skin Irrit. 2; Eye <= 100 %
EC-No.259-931-8Irrit. 2; STOT SE 3; H302,
H315, H319, H335
Hazardous ingredients according to Directive 1999/45/EC
ComponentClassificationConcentration
Nitazoxanide
CAS-No.55981-09-4Xn, R22 - R36/37/38<= 100 %
EC-No.259-931-8
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16
SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye